1st International Course on
Integrated Biomarkers

Biochemical and Bioimaging Endpoints in Cardiocerebrovascular Diagnosis,
Prevention, Therapy and Drug Development


Biomarkers 2005

To facilitate the dialogue among the multidisciplinary scientists, definition of the acronyms and of more specialized terms have been reported. Every amendment is welcome.

Andrea P. Peracino
Stefano Bellosta
Nicola Ferri
Riccardo Roggeri

International Normalized Ratio (INR) - The accuracy of the Prothrombin Time (PT) is known to be very system-dependent. The World Health Organization has addressed this system variability problem by the establishment of primary and secondary international reference preparations of thromboplastin and the development of a statistical model for the calibration of thromboplastins to derive the International Sensitivity Index (ISI) and to equate all thromboplastins to the reference thromboplastin through the following equation: INR = (patient PT/mean normal PT)isi


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