Biochemical
and Bioimaging Endpoints in Cardiocerebrovascular Diagnosis,
Prevention, Therapy and Drug Development
GLOSSARY
To
facilitate the dialogue among the multidisciplinary scientists,
definition of the acronyms and of more specialized terms have been
reported.
Every amendment is welcome.
By: Andrea P. Peracino
Stefano Bellosta
Nicola Ferri
Riccardo Roggeri
International Normalized Ratio (INR) - The accuracy of the Prothrombin Time (PT) is known to be very system-dependent. The World Health Organization has addressed this system variability problem by the establishment of primary and secondary international reference preparations of thromboplastin and the development of a statistical model for the calibration of thromboplastins to derive the International Sensitivity Index (ISI) and to equate all thromboplastins to the reference thromboplastin through the following equation: INR = (patient PT/mean normal PT)isi
