1st International Course on
Integrated Biomarkers

Biochemical and Bioimaging Endpoints in Cardiocerebrovascular Diagnosis,
Prevention, Therapy and Drug Development


Biomarkers 2005

To facilitate the dialogue among the multidisciplinary scientists, definition of the acronyms and of more specialized terms have been reported. Every amendment is welcome.

Andrea P. Peracino
Stefano Bellosta
Nicola Ferri
Riccardo Roggeri

hypoxia-inducible transcription factors (HIF) -1 and -2, oxygen-regulated -subunits of two principal mediators of adaptation to critically low oxygen levels. Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric peptide that is a key regulator of genes such as heme oxygenase (HO)-1 expressed under hypoxic conditions. We hypothesized that HO-1 plays an important role in regulating proinflammatory mediator production under conditions of ischemia-reperfusion.


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