A characteristic that is objectively measured (by biochemical, or imaging methodology, including molecular medicine) and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.
• Biomarker is a cellular, or molecular indicator of exposure, health effects, or susceptibility.
• Biomarker can be detected, or described, by chemical, physical, and physico-chemical methodologies
• Biomarker can be represented by a measure (biochemical), or a morphology (imaging), or a function
• Biomarkers can be used to inform about an internal dose, a biologically effective dose, an early biological response, an altered structure or function, a susceptibility