Biochemical
and Bioimaging Endpoints in Cardiocerebrovascular Diagnosis,
Prevention, Therapy and Drug Development
GLOSSARY
To
facilitate the dialogue among the multidisciplinary scientists,
definition of the acronyms and of more specialized terms have been
reported.
Every amendment is welcome.
By: Andrea P. Peracino
Stefano Bellosta
Nicola Ferri
Riccardo Roggeri
A characteristic that is objectively measured (by biochemical, or imaging methodology, including molecular medicine) and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention.
• Biomarker is a cellular, or molecular indicator of exposure, health effects, or susceptibility.
• Biomarker can be detected, or described, by chemical, physical, and physico-chemical methodologies
• Biomarker can be represented by a measure (biochemical), or a morphology (imaging), or a function
• Biomarkers can be used to inform about an internal dose, a biologically effective dose, an early biological response, an altered structure or function, a susceptibility
