1st International Course on
Integrated Biomarkers

Biochemical and Bioimaging Endpoints in Cardiocerebrovascular Diagnosis,
Prevention, Therapy and Drug Development


Biomarkers 2005

To facilitate the dialogue among the multidisciplinary scientists, definition of the acronyms and of more specialized terms have been reported. Every amendment is welcome.

Andrea P. Peracino
Stefano Bellosta
Nicola Ferri
Riccardo Roggeri

Angiotensin II is the final active messenger of the renin-angiotensin pathway Angiotensin II binds to AT1 receptors to cause vasoconstriction and fluid retention, both of which lead to an increase in blood pressure. The angiotensin II receptor blockers lower blood pressure by blocking the AT1 receptors.

A medicine that lowers blood pressure by blocking the action of angiotensin II

Endothelium in Atherogenesis
Endothelium in Atherogenesis: the early endothelium damage is prompeted by several factors icluding oxidised LDL, with protective effect of HDL; activated neutrophiles and macrophages adher to the damaged endothelium; activated macrophages become foam cells by uptake of oxidized LDL, and synthetize Angiotensin II to promotes oxidative stress caused by reactive oxygene species (ROS) ant stimulate the formation of VICAM, and promotes growth of Vascular Smooth Cells (VSM)


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