1st International Course on
Integrated Biomarkers

Biochemical and Bioimaging Endpoints in Cardiocerebrovascular Diagnosis,
Prevention, Therapy and Drug Development


Biomarkers 2005

To facilitate the dialogue among the multidisciplinary scientists, definition of the acronyms and of more specialized terms have been reported. Every amendment is welcome.

Andrea P. Peracino
Stefano Bellosta
Nicola Ferri
Riccardo Roggeri

Thrombomodulin is an integral protein that contains one chondroitin/ dermatan sulphate chain. It binds to thrombin and act as a cofactor in the activation of protein C catalyzed by thrombin. Glycosaminoglycan chain is not necessary for the activation, but it may be important in preventing thrombin bound to thrombomodulin to cleave fibrinogen. Its core protein contains a short cytoplasmic domain that has a homology with LDL-receptor


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