1st International Course on
Integrated Biomarkers

Biochemical and Bioimaging Endpoints in Cardiocerebrovascular Diagnosis,
Prevention, Therapy and Drug Development


Biomarkers 2005

To facilitate the dialogue among the multidisciplinary scientists, definition of the acronyms and of more specialized terms have been reported. Every amendment is welcome.

Andrea P. Peracino
Stefano Bellosta
Nicola Ferri
Riccardo Roggeri

Interleukins are a group of cytokines that are expressed by white blood cells (leukocytes, hence the -leukin) as a means of communication (inter-). A list of interleukins with function: IL-1: (secreted by macrophages), induces acute phase reaction IL-2: (secreted by T cells) stimulates growth and differentiation of T cell response. IL-3: (secreted by T cells), stimulates bone marrow stem cells. IL-4: involved in proliferation of B cells, and the development of T cells and mast cells. Role in allergic responses. IL-5: role in stimulation of B cells, eosinophil production, IgA production IL-6: (secreted by macrophages) induces acute phase reaction IL-7: involved in B, T and NK cell survival, development and homeostasis IL-8: Neutrophil chemotaxis IL-9: stimulates mast cells IL-10: inhibits Th1 cytokine production IL-11: acute phase protein production IL-12: NK cell stimulation, Th1 cells induction IL-13: Stimulates growth and differentiation of B-Cells, inhibits Th1 cells and the production of macrophage inflammatory cytokines IL-17: Induces production of inflammatory cytokines IL-18: Induces production of Interferon-Gamma (IFNy)


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