1st International Course on
Integrated Biomarkers

Biochemical and Bioimaging Endpoints in Cardiocerebrovascular Diagnosis,
Prevention, Therapy and Drug Development

GLOSSARY

Biomarkers 2005


To facilitate the dialogue among the multidisciplinary scientists, definition of the acronyms and of more specialized terms have been reported. Every amendment is welcome.

By:
Andrea P. Peracino
Stefano Bellosta
Nicola Ferri
Riccardo Roggeri


Definition:
Description:
References:
Any protein whose plasma concentration increases (or decreases) by 25% or more during certain inflammatory disorders. The acute-phase proteins include C-reactive protein (CRP), Serum Amyloid A (SAA), Fibrinogen, and alpha 1-acid glycoprotein

plasma protein

Coronary artery inflammation is involved in all stages of atherosclerotic plaque formation. Plaque rupture and erosions precipitate thrombosis in patients with acute myocardial infarction (AMI), unstable angina, stenosis, total vessel occlusion, and sudden death. The thin, fibrous cap overlying the lipid-rich core of unstable plaques contains inflammatory cells that include proteins such as fibrinogen and CRP, which are important determinants of plaque rupture .see also the Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association


 

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